منابع مشابه
Intracellular Cholesterol Efflux
A 48-yr-old Caucasian female of central European origin (subject IM) with low plasma cholesterol and normal plasma triglyceride (TG) had extremely low apo A-I (6 mg/dl), A-II (5 mg/dl), and HDL cholesterol (2 mg/dl) levels. She had most of the clinical symptoms typically associated with Tangier disease, including early corneal opacities, yellow-streaked tonsils, hepatomegaly, and variable degre...
متن کاملTargeted cholesterol efflux
www.landesbioscience.com Cell Cycle 3345 In the process of reverse cholesterol transport, high-density lipoprotein (HDL) transports excess cholesterol from peripheral cells back to the liver, where cholesterol is recycled or metabolized and excreted. On the cellular level, 2 membrane-associated ATP-binding cassette (ABC) cholesterol transporters, ABCA1 and ABCG1, play a major role in cholestero...
متن کاملApolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux.
Published data related to both cell membrane biology and apolipoprotein structure are reviewed and used to formulate a new model describing the mechanisms of cholesterol efflux from cell plasma membrane to high density lipoprotein (HDL) particles. The central premise of this model is the existence of heterogenous domains of cholesterol within plasma membranes. We propose that cholesterol efflux...
متن کاملCholesterol Efflux and Nascent HDL Formation
Cholesterol Efflux and Nascent HDL Formation The risk of developing coronary vascular disease (CVD) has been shown during many decades to be inversely correlated with plasma levels of high-density lipoprotein (HDL). However, recent studies suggest that HDL concentration does not always predict an individuals’ CVD risk; rather, the amount of cholesterol efflux from cells seems a better predictor...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2012
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.112.300134